Coriolus Polysaccharides Extraction Methods

The extraction of PSP (Polysaccharopeptide) and PSK (Polysaccharide Krestin) involves isolating specific protein-bound polysaccharides from cultured Coriolus versicolor (Turkey Tail) mycelium. While individual manufacturers use proprietary methods, the general production process follows similar principles.

Extraction of PSP

1. Source Material
   PSP is produced from cultured Coriolus versicolor mycelium using selected strains developed for PSP production (specifically the COV-1 strain).
2. Cultivation
   The mycelium is grown under carefully controlled conditions to optimise the production of bioactive compounds.
3. Harvesting
   Once sufficient growth has been achieved, the mycelium is harvested for extraction.
4. Extraction
   The cell walls are broken down using techniques such as hot water extraction, enzymatic treatment and other proprietary processes to release the polysaccharopeptides.
5. Purification
   The extract is filtered and purified to concentrate the desired bioactive compounds while removing unwanted material.
6. Drying
   The purified extract is dried into a stable powder suitable for formulation into dietary supplements.

Extraction of PSK

1. Source Material
   PSK is produced from cultured Coriolus versicolor mycelium using carefully selected production strains developed for PSK manufacture(specifically the CM-101 strain).
2. Cultivation
   The mycelium is cultivated under strictly controlled conditions to ensure consistent quality and production of the desired protein-bound polysaccharides.
3. Harvesting
   The cultured mycelium is harvested once optimal growth has been achieved.
4. Extraction
   Hot water extraction is commonly used to release the bioactive polysaccharides, followed by additional proprietary processing steps depending on the manufacturer.
5. Purification
   The extract is refined to concentrate the PSK fraction while maintaining product consistency and purity.
6. Drying
   The finished extract is dried into a stable powder suitable for pharmaceutical or dietary supplement use.

Although the general principles are similar, the precise extraction methods used to produce PSP and PSK differ between manufacturers and remain proprietary. Factors such as the production strain, cultivation conditions, extraction temperature, purification methods and quality control procedures all influence the composition, purity and consistency of the final extract.

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