PSK (Polysaccharide Krestin):
- Commonly used dosage in studies: 3 grams per day, often divided into three 1-gram doses. This dosage has been used as an adjuvant to chemotherapy for various cancers (e.g., colon, colorectal, gastric cancer) for up to 7 years.
- General safe consumption: Turkey Tail glucan products (including PSK) have been safely consumed at doses of 1 gram or more per day for up to 10 years in cancer patients.
- Maximum tolerated dose (MTD) in a clinical trial: One study involving women with breast cancer found that up to 9 grams/day of a Trametes versicolor preparation was safe and tolerable.
PSP (Polysaccharide Peptide):
- Commonly used dosage: 3.06 grams per day for 1 month has been administered to patients with stage III to IV non-small cell lung cancer.
- Prebiotic use: 1,080 mg (3 capsules) 3 times daily has been used as a prebiotic.
- General safe consumption: Similar to PSK, PSP products have been safely consumed at doses of 1 gram or more per day for up to 10 years in cancer patients.
Purpose of Use: Dosages may differ depending on the specific health concern you are addressing. Clinical trials for cancer often use higher doses than those for general immune support. - Individual Variation: Factors like age, overall health, and other medications can influence how a person responds to supplements.
Consult a Healthcare Professional:
- It is always recommended to consult with a doctor or qualified healthcare professional before starting any new supplement, especially for conditions like cancer, to determine the appropriate dosage and to ensure it won't interact with any existing medications or conditions.
While specific "maximum daily dosages" are not rigidly defined for all circumstances, the research suggests that PSK and PSP from Turkey Tail mushroom are generally well-tolerated at several grams per day, with some studies exploring up to 9 grams/day.
