When it comes to natural immune support and complementary cancer therapies, two names often come up: PSK (Polysaccharide-K, also known as Krestin) and PSP (Polysaccharopeptide). Both are extracts from the Turkey Tail mushroom (Coriolus versicolor), celebrated for their immune-boosting benefits. But what’s the real difference between PSK and PSP—and when should you consider one over the other?
What Are PSK and PSP?
Both PSK and PSP are protein-bound polysaccharides derived from the mycelium of Turkey Tail mushrooms. Each has a unique discovery story and slightly different molecular structures, resulting in variations in their clinical applications and research focus.
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PSK was developed in Japan in the 1970s and quickly became a standard complementary therapy in Japanese hospitals, especially for cancer patients.
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PSP emerged in China in the 1980s and has become a popular supplement for immune health and liver support, with growing research behind it.
Key Differences Between PSK and PSP
| PSK (Krestin) | PSP | |
|---|---|---|
| Origin | Japan | China |
| Structure | Protein-bound β-glucans, unique molecular weight | Polysaccharopeptides, slightly different structure |
| Research | Hundreds of clinical trials, especially for cancer support | Significant research, especially for liver health and immunity |
| Medical Approval | Approved in Japan for cancer therapy | Used as a supplement in China; not officially a pharmaceutical |
| Main Uses | Cancer adjuvant, immune modulation | Immune support, liver protection, cancer support |
When Should You Use PSK or PSP?
PSK: The Japanese Standard for Cancer Support
PSK is best known for its role as an adjunct to conventional cancer therapies. Japanese hospitals frequently use PSK alongside chemotherapy for cancers such as stomach, colon, lung, and breast cancer. Clinical studies show that PSK can enhance immune response, improve treatment outcomes, and reduce chemotherapy side effects. For those undergoing cancer treatment or recovering from illness, PSK offers strong, research-backed support.
PSP: China’s Immune and Liver Health Ally
PSP is commonly used in China for its broad immune-enhancing and liver-protective effects. It’s popular not only among cancer patients, but also with anyone looking to strengthen immune defenses or support liver health. Studies suggest that PSP can be helpful for people with chronic hepatitis, liver cirrhosis, or anyone wanting a daily boost to their immune system.
Which One Should You Choose?
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Choose PSK if:
You are looking for a well-studied adjunct to cancer treatment, especially if following protocols used in Japan. -
Choose PSP if:
You want broad-spectrum immune support, liver protection, or a daily wellness supplement, in line with practices in China.
Final Thoughts
While PSK and PSP are both derived from the same remarkable mushroom, their unique histories, research backgrounds, and benefits set them apart. Both are considered very safe, natural ways to support the immune system and overall health.
